Description
Thymosin Beta-4 Fragment (TB-500)
Thymosin Beta-4 Fragment (TB-500) is a synthetically manufactured, highly purified peptide representing the active core sequence of the naturally occurring human protein Thymosin Beta-4. Consisting of a precise 7-amino-acid chain sequence (Ac-Ser-Asp-Lys-Pro-Dmp-Ala-Glu), this specific low-molecular-weight acetylated fragment retains the full biological activity of the parent molecule while exhibiting superior cellular permeability due to its reduced size. In peer-reviewed biochemical literature, this compound is utilized as a primary tool for evaluating actin-sequestration mechanics, cellular migration kinetics, endothelial cell differentiation, and matrix metalloproteinase regulation in in vitro and in vivo laboratory research models. [1, 2, 3, 4, 5]
Our Thymosin Beta-4 Fragment reagent is synthesized utilizing advanced solid-phase peptide synthesis (SPPS) methodologies and high-performance liquid chromatography (HPLC) purification protocols. This process yields a pristine, highly stable lyophilized white crystalline powder cake optimized for chemical consistency, structural longevity, and reproducible results across high-throughput analytical screening. [1, 2]
Product Specifications
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- Compound Name: Thymosin Beta-4 Fragment (TB-500 Core Fragment)
- Sequence Matrix: Ac-SDKPDMAE
- Molecular Formula: C₃₈H₆₁N₉O₁₄
- Molecular Weight: 883.94 g/mol
- Physical Form: Lyophilized Crystalline Powder
- Purity Matrix: >99.0% (Verified via HPLC & Mass Spectrometry)
- Source: Synthesized in the USA
- Packaging: Single 10mg vacuum-sealed glass vial (3mL configuration) [1, 2, 3, 4, 5]
Reconstitution & Laboratory Storage
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- Lyophilized Storage: To maintain optimal structural integrity and prevent natural peptide degradation, store the dry powder cake continuously frozen at or below -20°C prior to evaluation. Stable under properly desiccated conditions for up to 24 months from the manufacturing date.
- Reconstitution Guidelines: Allow the glass vial to naturally acclimatize to room temperature before introducing an appropriate laboratory solvent, such as a sterile laboratory reagent. Gently swirl the container until the white powder dissolves completely. Do not shake or agitate aggressively, as high kinetic force can destabilize and fracture delicate peptide bonds. [1]
- Post-Reconstitution Storage: Once liquid solution has been introduced, store continuously refrigerated between 2°C and 8°C (36°F to 46°F). Protect entirely from prolonged exposure to direct light or ambient UV radiation. Utilize within 30 days of fluid integration. [1]
Regulatory & Safety Disclosure
LABORATORY RESEARCH USE ONLY. This synthesized product is a purified chemical reagent intended exclusively for in vitro scientific research, biochemical analysis, and forensic evaluation. It is strictly NOT FOR HUMAN CONSUMPTION, therapeutic administration, clinical trials, or domestic diagnostic applications. This material must be handled exclusively by qualified, trained laboratory personnel utilizing appropriate personal protective equipment (PPE). [1, 2, 3, 4, 5]
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